Ivermectin B1a
Avermectin A1a, 5-O-demethyl-22,23-dihydro-
CAS: 71827-03-7
Molecular Formula: C48H74O14
Ivermectin B1a - Names and Identifiers
| Name | Avermectin A1a, 5-O-demethyl-22,23-dihydro- |
| Synonyms | Ivermectin B1a IvermectinH2B1a Ivermectin Impurity 3 Dihydroavermectin B1a 5-O-Demethyl-22,23-dihydroavermectin A1a 22,23-Dihydro-5-O-demethylavermectin A1a Avermectin A1a, 5-O-demethyl-22,23-dihydro- (2Ae,4E,5'S,6S,6'R,7S,8E,11R,13R,15S,17ar,20R,20ar,20bs)-20,20B-dihydroxy-5',6,8,19-tetramethyl-6'-[(1S)-1-methylpropyl]-17-oxo-3',4',5',6,6',10,11,14,15,17,17A,20,20A,20B-tetradecahydro-2H,7H-spiro[11,15-methanofuro[4,3,2-pq][2,6]benzodioxacyclooctadecine-13,2'-pyran]-7-yl 2,6-dideoxy-4-o-(2,6-dideoxy-3-o-methyl-alpha-L-arabino-hexopyranosyl)-3-o-methyl-alpha-L-arabino-hexopyranoside |
| CAS | 71827-03-7 |
| EINECS | 276-046-2 |
Ivermectin B1a - Physico-chemical Properties
| Molecular Formula | C48H74O14 |
| Molar Mass | 875.09 |
| Density | 1.0683 (rough estimate) |
| Melting Point | 155-157° |
| Boling Point | 717.97°C (rough estimate) |
| pKa | 12.42±0.70(Predicted) |
| Refractive Index | 1.6130 (estimate) |
| In vitro study | Ivermectin belongs to the macrocyclic lactone class of avermectins and consists of a mixture of two homologous compounds, ivermectin B1a (not less than 80%) and ivermectin B1b (not more than 20%). Ivermectin B1a, the major component of Ivermectin, is inactive at a concentration of 0.3 μg/ml, whereas in the case of the minor component, ivermectin B1b, the same concentration produces 100% mortality of snails. |
Ivermectin B1a - Introduction
Ivermectin B1A is an antibiotic that belongs to the polyene class of antibiotics. It has a broad spectrum of antibacterial activity, and has a strong inhibitory effect on many bacteria, fungi and parasites. Ivermectin B1A is mainly used to treat various infectious diseases caused by sensitive bacteria, including respiratory tract, genitourinary system, skin and soft tissue infections.
The preparation method of ivermectin B1A is usually obtained by extracting and purifying the strain strettomyces erythorus that produces it by fermentation culture. The specific preparation method includes culturing the fermentation strain, collecting the fermentation liquid, separating and purifying by centrifugation, etc., and finally obtaining pure ivermectin B1A.
Regarding the safety information of ivermectin B1A, it is one of the commonly used antibiotics in clinical practice and is generally used for medical purposes. However, in the process of use, it is still necessary to pay attention to the following matters: use according to the doctor's advice, use according to the correct dosage and method of use; Avoid allergic reactions, and seek medical attention in time if allergic symptoms occur; In pregnant women, lactating women and children should pay special attention when using it; Some adverse reactions may occur, such as gastrointestinal reactions, skin allergies, etc. If there are serious reactions, seek medical attention immediately.
The preparation method of ivermectin B1A is usually obtained by extracting and purifying the strain strettomyces erythorus that produces it by fermentation culture. The specific preparation method includes culturing the fermentation strain, collecting the fermentation liquid, separating and purifying by centrifugation, etc., and finally obtaining pure ivermectin B1A.
Regarding the safety information of ivermectin B1A, it is one of the commonly used antibiotics in clinical practice and is generally used for medical purposes. However, in the process of use, it is still necessary to pay attention to the following matters: use according to the doctor's advice, use according to the correct dosage and method of use; Avoid allergic reactions, and seek medical attention in time if allergic symptoms occur; In pregnant women, lactating women and children should pay special attention when using it; Some adverse reactions may occur, such as gastrointestinal reactions, skin allergies, etc. If there are serious reactions, seek medical attention immediately.
Last Update：2024-04-09 21:54:55
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View History
Ivermectin B1a
2,6-Dimethyl-4-heptanone
2-ACETYLAMINO-3-CHLORO-PROPIONIC ACID METHYL ESTER
METHYLSULFONIC ANHYDRIDE
trans-Methyl-3-aminocyclohexanecarboxylatehydrochloride
3-bromo-5-methyl-pyrazin-2-amine
Phosphoric acid dihydrogen 2-ethylhexyl
1-Acetylimidazolidin-2-one
2-乙酰胺基丙烯酸甲酯
1-BENZOYL-4-CYANO-4-PHENYLPIPERIDINE HYDROCHLORIDE
2,6-Dimethyl-4-heptanone
2-ACETYLAMINO-3-CHLORO-PROPIONIC ACID METHYL ESTER
METHYLSULFONIC ANHYDRIDE
trans-Methyl-3-aminocyclohexanecarboxylatehydrochloride
3-bromo-5-methyl-pyrazin-2-amine
Phosphoric acid dihydrogen 2-ethylhexyl
1-Acetylimidazolidin-2-one
2-乙酰胺基丙烯酸甲酯
1-BENZOYL-4-CYANO-4-PHENYLPIPERIDINE HYDROCHLORIDE